Depolarization induces calcium-dependent BMP4 release from mouse embryonic palate mesenchyme.

Mikaela L Follmer Trevor Isner Yunus H Ozekin Claire Levitt Emily Anne Bates

Published in: bioRxiv : the preprint server for biology (2024)

We show that embryonic palate mesenchyme cells undergo transient changes in intracellular calcium. Depolarization of these cells induces BMP4 release suggesting that ion channels are a node in BMP4 signaling.

Keyphrases

induced apoptosis
mesenchymal stem cells
cell cycle arrest
bone regeneration
endoplasmic reticulum stress
lymph node
cell death
signaling pathway
oxidative stress
cell proliferation