Metabolomics reveals biomarkers in human urine and plasma to predict cytochrome P450 2D6 (CYP2D6) activity.

Gaelle MaglioccoJules DesmeulesAlain MattheyLuis M Quirós-GuerreroNasim BararpourTimothée JoyeLaurence MarcourtEmerson F QueirozJean-Luc WolfenderYvonne GloorAurélien ThomasYoussef Daali

Published in: British journal of pharmacology (2021)

The applied untargeted metabolomic strategy identified potential novel markers capable of semi-quantitatively predicting CYP2D6 activity, a promising discovery for personalized medicine.

Keyphrases

mass spectrometry
endothelial cells
small molecule
high throughput
induced pluripotent stem cells
liquid chromatography
risk assessment
gas chromatography mass spectrometry
human health
high resolution mass spectrometry