Adipose Tissue Mitochondrial Factors Profile after Dietary Bioactive Compound Weight Reduction Treatments in a Mice Obesity Model.
Anna CassanyeMeritxell Martín-GariManuel Portero-OtinJose Carlos SerranoPublished in: International journal of molecular sciences (2019)
Prolonged caloric intake above energy needs disturbs the body's ability to store and manage the excess of energy intake, leading to the onset of chronic degenerative diseases. This study aimed to compare the effect of three foods, which contain demonstrated bioactive compounds in the treatment of obesity and as an adjuvant in obesity energy restriction treatments. In a mice obesity model induced through a high-fat diet; fish oil, soluble fibre, and soy were incorporated to evaluate its capacity to modulate metabolic factors in adipose tissue during a continued fat intake or weight reduction through a normocaloric diet. As a result, fish oil improved mitochondrial related, adipose tissue hormone expression, and oxidation products when high-fat diets are consumed; while soluble fibre improved glucose and inflammation pathways during high-fat diet intake. In weight reduction treatments few differential features, as a treatment adjuvant, were observed for fish oil and soy; while soluble fibre was able to improve the weight reduction effects induced by a normocaloric diet. As a conclusion, soluble fibre supplementation compared to an energy reduction program, was the only treatment able to induce a significant additional effect in the improvement of weight loss and adipose tissue metabolism.
Keyphrases
- weight loss
- adipose tissue
- high fat diet
- insulin resistance
- weight gain
- high fat diet induced
- bariatric surgery
- roux en y gastric bypass
- gastric bypass
- type diabetes
- body mass index
- metabolic syndrome
- physical activity
- oxidative stress
- early stage
- blood pressure
- obese patients
- quality improvement
- skeletal muscle
- binding protein
- drug induced