Differential T-Cell Immunity to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in mRNA-1273- and BNT162b2-Vaccinated Individuals.

Kathleen M E GallagherMark B LeickRebecca C LarsonTrisha R BergerKatelin KatsisJennifer Y YamMarcela V Maus

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

COVID-19 breakthrough cases among vaccinated individuals demonstrate the value of measuring long-term immunity to SARS-CoV-2 and its variants. We demonstrate that anti-spike T-cell responses and IgG antibody levels are maintained but decrease over time and are lower in BNT162b2- versus mRNA-1273-vaccinated individuals. T-cell responses to the variants are relatively unaffected.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
copy number
gene expression