Oncostatin M Induces a Pro-inflammatory Phenotype in Intestinal Subepithelial Myofibroblasts.
Georgios KokkotisEirini FilidouGesthimani TarapatziMichail SpathakisLeonidas KandilogiannakisNikolas DovrolisKonstantinos ArvanitidisIoannis DrygiannakisVassilis ValatasStergios VradelisVangelis G ManolopoulosVasilis PaspaliarisGeorge KoliosGiorgos BamiasPublished in: Inflammatory bowel diseases (2024)
Human SEMFs overexpress OSMR in an inflammatory microenvironment. Oncostatin-M may promote inflammation in IBD via its stimulatory effects on SEMFs, which primarily involve chemoattraction of immune cells to the intestinal mucosa.