A novel oncolytic virus induces a regional cytokine storm and safely eliminates malignant ascites of colon cancer.

Shuang DongBinlei LiuSheng HuFang GuoYi ZhongQian CaiSiqi ZhangYu QianJun WangYingying Shi

Published in: Cancer medicine (2022)

OH2 could safely eliminate malignant ascites of colon cancer and convert the cold immune microenvironment by inducing a remarkably regional cytokine storm in ascites, mainly IL-6, in the early stage of antitumor immune responses beyond directed oncolytic virotherapy.

Keyphrases

cell free
early stage
immune response
stem cells
dendritic cells
toll like receptor
sentinel lymph node
radiation therapy