Cerebral microvascular dysfunction in metabolic syndrome is exacerbated by ischemia-reperfusion injury.
Nathalie ObadiaMarcos Adriano LessaAnissa DaliryRaquel Rangel SilvaresFabiana GomesEduardo TibiriçáVanessa EstatoPublished in: BMC neuroscience (2017)
Our results demonstrate that during ischemia and reperfusion, animals with MetS are more susceptible to alterations in the cerebral microcirculation involving endothelial dysfunction and oxidative stress events.
Keyphrases
- oxidative stress
- ischemia reperfusion injury
- cerebral ischemia
- metabolic syndrome
- subarachnoid hemorrhage
- diabetic rats
- dna damage
- brain injury
- induced apoptosis
- acute myocardial infarction
- blood brain barrier
- insulin resistance
- cerebral blood flow
- adipose tissue
- uric acid
- type diabetes
- acute ischemic stroke
- heart failure
- cardiovascular disease
- coronary artery disease
- signaling pathway
- heat shock
- endoplasmic reticulum stress