Systematic characterization of non-coding RNAs in triple-negative breast cancer.
Jie MeiLeiyu HaoHuiyu WangRui XuYan LiuYichao ZhuChaoying LiuPublished in: Cell proliferation (2020)
Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with negativity for oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2). Non-coding RNAs (ncRNAs) make up most of the transcriptome and are widely present in eukaryotic cells. In recent years, emerging evidence suggests that ncRNAs, mainly microRNAs (miRNAs), long ncRNAs (lncRNAs) and circular RNAs (circRNAs), play prominent roles in the tumorigenesis and development of TNBC, but the functions of most ncRNAs have not been fully described. In this review, we systematically elucidate the general characteristics and biogenesis of miRNAs, lncRNAs and circRNAs, discuss the emerging functions of these ncRNAs in TNBC and present future perspectives in clinical practice.
Keyphrases
- epidermal growth factor receptor
- clinical practice
- tyrosine kinase
- advanced non small cell lung cancer
- endothelial cells
- induced apoptosis
- estrogen receptor
- gene expression
- single cell
- cell cycle arrest
- network analysis
- rna seq
- oxidative stress
- binding protein
- genome wide analysis
- endoplasmic reticulum stress
- endoplasmic reticulum
- young adults