Graft versus host disease after liver transplantation: A case report.
Sencan AcarMutlu AratTülay TecimerKamil Yalçın PolatMurat AkyildizPublished in: Hepatology forum (2022)
Graft Versus Host Disease (GVHD) is a severe immunological-clinicopathological condition mediated by healthy T-lymphocytes in donor tissue against the immunosuppressed host tissue and rarely seen after solid organ transplantation (SOT). A 72-year old male patient underwent cadaveric liver transplantation. On day 34 of the postoperative follow-up, the patient developed fever, generalized skin rash and hemorrhagic lesions in the oropharynx. Skin biopsy was consistent with GVHD. Despite high-dose corticosteroid treatment, he died on postoperative day 51. Although it is seen rarely after liver transplantation, GVHD is an important clinical entity for which early diagnosis is critical due to its high rates of mortality.
Keyphrases
- high dose
- allogeneic hematopoietic stem cell transplantation
- patients undergoing
- case report
- soft tissue
- ultrasound guided
- wound healing
- low dose
- early onset
- cardiovascular events
- stem cells
- type diabetes
- acute lymphoblastic leukemia
- stem cell transplantation
- cardiovascular disease
- fine needle aspiration
- cell therapy
- bone marrow