Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice.
Leticia Maria de Souza CordeiroArwa ElsheikhNagavardhini DevisettyDonald A MorganSteven N EbertKamal RahmouniKavaljit H ChhabraPublished in: Diabetologia (2020)
These findings define a previously unrecognised function of hypothalamic MC4R in glucose reabsorption mediated by adrenaline and renal GLUT2. Taken together, our findings indicate that elevated glucosuria due to low sympathetic tone explains why MC4R deficiency does not cause hyperglycaemia despite inducing obesity and insulin resistance. Graphical abstract.