Strong coupling between slow oscillations and wide fast ripples in children with epileptic spasms: Investigation of modulation index and occurrence rate.

Yasuhiro IimuraKevin JonesLynne TakadaItsuki ShimizuMisaki KoyamaKyoko HattoriYushi OkazawaYutaka NonodaEishi AsanoTomoyuki AkiyamaCristina GoAyako OchiO Carter SneadElizabeth J DonnerJames T RutkaJames M DrakeHiroshi Otsubo

Published in: Epilepsia (2018)

In ES+, the larger number of high-rate FR electrodes indicates more widespread epileptogenicity than in ES-. High values of OR(FRs) and MI(FRs & 3-4 Hz) in ES+ compared to ES- are a signature of the severity of epileptogenicity. We proved that ES+ children who achieved seizure freedom following multilobar resections exhibited strong coupling between slow oscillations and FRs.

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