Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review and meta-analysis.
Rathin GosaviClemente ChiaMichael MichaelAlexander G HeriotSatish K WarrierJoseph C KongPublished in: International journal of colorectal disease (2021)
Our systematic review and meta-analysis show that NAC is safe with an acceptable side effect profile in the management of LACC. The current data supports an oncological benefit for tumour downstaging and increased in R0 resection rate.
Keyphrases
- neoadjuvant chemotherapy
- locally advanced
- rectal cancer
- squamous cell carcinoma
- phase ii study
- sentinel lymph node
- radiation therapy
- lymph node
- transcription factor
- electronic health record
- big data
- prostate cancer
- radical prostatectomy
- clinical trial
- robot assisted
- machine learning
- data analysis
- study protocol
- genome wide analysis