Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study.

Päivi Herranen Kaisa Koivunen Teemu Palviainen Urho M Kujala Samuli Ripatti Jaakko A Kaprio Elina Sillanpäänull FinnGen

Published in: The journals of gerontology. Series A, Biological sciences and medical sciences (2024)

The genotype that supports higher muscle strength appears to protect against future health adversities, albeit with modest effect sizes. Further research is needed to investigate whether or how a favorable lifestyle modifies this intrinsic capacity to resist diseases, and if the impacts of lifestyle behavior on health differs due to genetic predisposition for muscle strength.

Keyphrases

genome wide
public health
healthcare
metabolic syndrome
mental health
cardiovascular disease
physical activity
dna methylation
weight loss
health information
copy number
health promotion
type diabetes
gene expression
risk assessment
current status