Azathioprine metabolite levels and outcomes during pregnancies with rheumatic disease.
Stephen J BalevicCatherine A SimsAmanda M EudyValerie SmithMegan E B ClowsePublished in: Lupus science & medicine (2024)
In this exploratory study, we did not observe systematic changes in 6-TGN concentrations throughout pregnancy and peripartum, whereas 6-MMPN concentrations were higher during pregnancy. Monitoring AZA metabolite concentrations in pregnancy is a potential tool to identify medication non-adherence as well as patients with high 6-MMPN in whom dosage adjustment or close laboratory monitoring may optimise safety.