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Knock-down of IGFBP2 ameliorates lung fibrosis and inflammation in rats with severe pneumonia through STAT3 pathway.

Yuyu WangJianjiang HuangFang ZhangKeli ShenBin Qiu
Published in: Growth factors (Chur, Switzerland) (2023)
Knock-down of IGFBP2 ameliorated lung injury in SP rats, inhibited inflammation and pulmonary fibrosis, and promoted M2-type transformation of AMs by activating the STAT3 pathway.
Keyphrases
  • pulmonary fibrosis
  • oxidative stress
  • cell proliferation
  • signaling pathway
  • early onset
  • mouse model
  • drug induced
  • liver fibrosis
  • acute respiratory distress syndrome