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Bad to the bone: B cell acute lymphoblastic leukemia cells mediate bone destruction.

Sujeetha A RajakumarJayne S Danska
Published in: Molecular & cellular oncology (2020)
Skeletal morbidities continue to cause acute and long-term burdens for B-ALL patients underscoring the need to identify the mechanisms underlying these processes and to develop effective therapies. Our recent findings demonstrated that B-ALL cells isolated at patient diagnosis can cause bone destruction and have identified the receptor activator of nuclear factor κ-B (RANK-RANKL) ligand axis as a critical effector of these effects.
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