Bad to the bone: B cell acute lymphoblastic leukemia cells mediate bone destruction.
Sujeetha A RajakumarJayne S DanskaPublished in: Molecular & cellular oncology (2020)
Skeletal morbidities continue to cause acute and long-term burdens for B-ALL patients underscoring the need to identify the mechanisms underlying these processes and to develop effective therapies. Our recent findings demonstrated that B-ALL cells isolated at patient diagnosis can cause bone destruction and have identified the receptor activator of nuclear factor κ-B (RANK-RANKL) ligand axis as a critical effector of these effects.
Keyphrases
- nuclear factor
- induced apoptosis
- acute lymphoblastic leukemia
- bone mineral density
- toll like receptor
- bone loss
- cell cycle arrest
- end stage renal disease
- soft tissue
- newly diagnosed
- ejection fraction
- endoplasmic reticulum stress
- prognostic factors
- signaling pathway
- inflammatory response
- regulatory t cells
- case report
- drug induced
- dendritic cells
- allogeneic hematopoietic stem cell transplantation
- extracorporeal membrane oxygenation
- type iii
- aortic dissection