Host Lipidome and Tuberculosis Treatment Failure.
Rupak ShivakotiJohn W NewmanLuke Elizabeth HannaArtur T L QueirozKamil BorkowskiAkshay N GupteMandar ParadkarPattabiraman SatyamurthiVandana KulkarniMurugesh SelvaNeeta PradhanShri Vijay Bala Yogendra ShivakumarSaravanan NatarajanRamesh KarunaiananthamNikhil GupteKannan ThiruvengadamOliver FiehnRenu BharadwajAnju KagalSanjay GaikwadShashikala SangleJonathan E GolubBruno Bezerril AndradeVidya MaveAmita GuptaChandrasekaran PadmapriyadarsiniPublished in: The European respiratory journal (2021)
We identified lipids, some with known roles in TB pathogenesis, associated with TB treatment failure. A lipid signature with prognostic accuracy for TB treatment failure was also identified. These lipids could be potential targets for risk-stratification, adjunct therapy and treatment monitoring.