Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides.
Denis V SudarikovYulia V GyrdymovaAlexander V BorisovJulia M LukiyanovaRoman V RumyantcevOksana G SchevchenkoDiana R BaidamshinaNargiza D ZakarovaAirat R KayumovEkaterina O SinegubovaAlexandrina S VolobuevaVladimir V ZarubaevSvetlana A RubtsovaPublished in: Molecules (Basel, Switzerland) (2022)
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48-88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73-95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.
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