Temporal shifts in safety and efficacy profile of mycophenolate mofetil 2 g versus 3 g daily early after heart transplantation.
Lorenzo BraghieriDouglas L JenningsBruno BohnMarlena HabalAlberto PinsinoGiulio M MondelliniAnnamaria LadanyiFarhana LatifKevin ClerkinSusan RestainoPaul KurlanskyKoji TakedaYoshifumi NakaRyan T DemmerGabriel T SayerNir UrielPaolo C ColomboMelana YuzefpolskayaPublished in: Pharmacotherapy (2022)
MMF-LD was associated with higher rates of early high-grade ACR and lower rates of later neutropenia. Further studies are warranted to test whether temporal MMF dose adjustments and gut microbial composition could improve clinical outcomes post-HT.