The protein phosphatase PPKL is a key regulator of daughter parasite development in Toxoplasma gondii .
Chunlin YangEmma H DoudEmily SampsonGustavo ArrizabalagaPublished in: bioRxiv : the preprint server for biology (2023)
, like other members of the phylum Apicomplexa, has numerous plant-like proteins, many of which play crucial roles and do not have equivalents in the mammalian host. In this study, we found that the plant-like protein phosphatase, PPKL, appears to be a key regulator of daughter parasite development. With the depletion of PPKL, the parasite shows severe defects in forming daughter parasites. This study provides novel insights into the understanding of parasite division and offers a new potential target for the development of antiparasitic drugs.