The Alzheimer's disease risk factor INPP5D restricts neuroprotective microglial responses in amyloid beta-mediated pathology.
Joshua D SamuelsKatelyn A MooreHannah E EnnerfeltAlexis M JohnsonAdeline E WalshRichard J PriceJohn R LukensPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2023)
Inpp5d deficiency in microglia increases plaque-associated microglia numbers. Loss of Inpp5d induces activation and phagocytosis transcriptional pathways. Plaque encapsulation and engulfment by microglia are enhanced with Inpp5d deletion. Genetic ablation of Inpp5d protects against plaque-induced neuronal dystrophy.
Keyphrases
- inflammatory response
- neuropathic pain
- coronary artery disease
- gene expression
- risk factors
- lps induced
- lipopolysaccharide induced
- cerebral ischemia
- spinal cord
- cognitive decline
- spinal cord injury
- early onset
- drug induced
- transcription factor
- genome wide
- diabetic rats
- brain injury
- mild cognitive impairment
- copy number
- catheter ablation