Molecular effects of polystyrene nanoplastics on human neural stem cells.
Raquel Martín FolgarMaría Del Carmen González-CaballeroMónica Torres-RuizAna I Cañas-PortillaMercedes de Alba GonzálezIsabel ListeMónica MoralesPublished in: PloS one (2024)
Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) after 4 days of exposure to 30 nm polystyrene (PS) NPs (0.5, 2.5 and 10 μg/mL). Our results showed that NPs can induce oxidative stress, cellular stress, DNA damage, alterations in inflammatory response, and apoptosis, which could lead to tissue damage and neurodevelopmental diseases.
Keyphrases
- oxidative stress
- dna damage
- endothelial cells
- inflammatory response
- neural stem cells
- risk assessment
- human health
- induced pluripotent stem cells
- healthcare
- oxide nanoparticles
- climate change
- cell death
- dna repair
- induced apoptosis
- diabetic rats
- lipopolysaccharide induced
- immune response
- cell proliferation
- photodynamic therapy
- cell cycle arrest
- single molecule
- stress induced
- health promotion