PD-1/PD-L1 Provides Protective Role in Hypoxia-Induced Pulmonary Vascular Remodeling.
Lei WangMi MuYu GuoJing HuangRuoyang ZhangMuzhi ZhangYue HuYanhua WangZhenqiang GaoLin LiuWang WangYuli ChengXin-Ping ZhuJie LiuWei WangYing SunPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
PD-1/PD-L1 plays a role in ameliorating HPH development by inhibiting T helper 17 cell response through the PI3K/AKT/mTOR pathway and improving endothelial dysfunction, suggesting a novel therapeutic indication for PD-1/PD-L1-based immunomodulatory therapies in the treatment of HPH.