Enalapril Is Superior to Lisinopril in Improving Endothelial Function without a Difference in Blood-Pressure-Lowering Effects in Newly Diagnosed Hypertensives.
Attila Csaba NagyRéka MájerJudit BoczánSándor SipkaAttila SzabóEnikő Edit EnyediOttó TataiMiklós FagyasZoltán PappLászló CsibaAttila TóthPublished in: Biomedicines (2023)
The blood-pressure-lowering effects of ACE inhibitor drugs are independent of their lipophilicity. In contrast, the effects of ACE inhibition on arterial endothelial function are associated with lipophilicity: the hydrophilic lisinopril was unable to improve, while the lipophilic enalapril significantly improved endothelial function. Moreover, the effects on blood pressure and endothelial function did not correlate in lisinopril-treated patients, suggesting divergent mechanisms in the regulation of blood pressure and endothelial function upon ACE inhibitory treatment.
Keyphrases
- blood pressure
- newly diagnosed
- hypertensive patients
- heart rate
- end stage renal disease
- angiotensin converting enzyme
- angiotensin ii
- chronic kidney disease
- ejection fraction
- blood glucose
- peritoneal dialysis
- magnetic resonance imaging
- computed tomography
- skeletal muscle
- metabolic syndrome
- patient reported outcomes
- drug induced
- adipose tissue
- high resolution
- combination therapy
- insulin resistance