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Pharmaco-epidemiology of antidepressant exposure in a UK cohort record-linkage study.

Jonathan D HaffertyEleanor M WigmoreDavid M HowardMark J AdamsToni-Kim ClarkeArchie I CampbellDonald J MacIntyreKristin K NicodemusStephen M LawrieDavid J PorteousAndrew M McIntosh
Published in: Journal of psychopharmacology (Oxford, England) (2019)
Antidepressant prevalence is greater than previously reported but incidence remains relatively stable. We found the majority of antidepressant episodes to be of relatively long duration with good estimated adherence. Our study supports the hypothesis that increased long-term use among existing (and returning) users, along with wider ranges of indications for antidepressants, has significantly increased the prevalence of these medications.
Keyphrases
  • major depressive disorder
  • risk factors
  • type diabetes
  • gene expression
  • adipose tissue
  • skeletal muscle
  • hepatitis c virus
  • men who have sex with men