CYP2D6 genotyping and the clinical impact on outcomes in breast cancer tamoxifen-treated patients.
Gabriel RamírezMarcelo VitalCarolina VergaraFlorencia CarussoFlorencia NeffaAdriana Della VallePatricia EsperónPublished in: Personalized medicine (2023)
Aims: To report the distribution of allele frequencies of CYP2D6 gene and to evaluate their influence on the clinical outcomes of a group of breast cancer patients receiving adjuvant tamoxifen treatment from Uruguay. Patients & methods: 199 samples were genotyped through real-time polymerase chain reaction assays. Metabolization profiles were inferred from the genotypes. Correlations were evaluated using Pearson's χ 2 test. Results: Phenotype frequencies were 0.65 normal (NM), 0.30 intermediate (IM) and 0.05 poor metabolizers (PM). Similar clinical outcomes between NM and (PM + IM) patient groups (odds ratio = 1.011, 95% CI = 0.2703-3.7826; p = 0.987) were found. Conclusion: CYP2D6 allele frequencies were analyzed for the first time in a cohort from Uruguay. Results did not support any impact of CYP2D6 gene polymorphisms on clinical outcomes.
Keyphrases
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- air pollution
- peritoneal dialysis
- early stage
- heavy metals
- high throughput
- particulate matter
- photodynamic therapy
- genome wide
- type diabetes
- adipose tissue
- metabolic syndrome
- gene expression
- breast cancer cells
- copy number
- estrogen receptor
- skeletal muscle
- dna methylation
- patient reported
- breast cancer risk