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Electrochemical selenylative ipso -annulation of N -benzylacrylamides to construct seleno-azaspiro[4.5]decadienones.

Raji Reddy ChadaJannatul IslamThallamapuram NagendraprasadUprety Ajaykumar
Published in: Organic & biomolecular chemistry (2024)
Herein, we present the electrochemical synthesis of selenylated azaspiro[4.5]decadienones through domino selenylation/ ipso -annulation of N -benzylacrylamides with diselenides. The method showed a wide substrate scope under mild and external oxidant-free reaction conditions, involving the construction of C-Se and C-C bonds. Gram-scale synthesis and further functional group conversion of the product are also demonstrated.
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