Electrochemical selenylative ipso -annulation of N -benzylacrylamides to construct seleno-azaspiro[4.5]decadienones.
Raji Reddy ChadaJannatul IslamThallamapuram NagendraprasadUprety AjaykumarPublished in: Organic & biomolecular chemistry (2024)
Herein, we present the electrochemical synthesis of selenylated azaspiro[4.5]decadienones through domino selenylation/ ipso -annulation of N -benzylacrylamides with diselenides. The method showed a wide substrate scope under mild and external oxidant-free reaction conditions, involving the construction of C-Se and C-C bonds. Gram-scale synthesis and further functional group conversion of the product are also demonstrated.