Fast and Noninvasive Hair Test for Preliminary Diagnosis of Mood Disorders.
Magdalena Świądro-PiętońKai A MorawiecAnna WójtowiczSara ŚwiądroRafał KurczabDominika DudekRenata Wietecha-PosłusznyPublished in: Molecules (Basel, Switzerland) (2022)
The main objective of this study was to develop a test for the fast and noninvasive prediagnosis of mood disorders based on the noninvasive analysis of hair samples. The database included 75 control subjects (who were not diagnosed with depression) and 40 patients diagnosed with mood disorders such as depression or bipolar disorder. Both women and men, aged 18-65 years, participated in the research. After taking the hair samples, they were washed (methanol-water-methanol by shaking in a centrifuge for two min) and air-dried in a fume hood. Each hair collection was analyzed using Fourier transform infrared spectroscopy attenuated total reflection (ATR-FTIR) spectroscopy. Subsequently, the results obtained were analyzed based on chemometric methods: hierarchical cluster analysis (HCA) and principal component analysis (PCA). As a results of the research conducted, potential differences were noticed. There was a visible change in the spectra intensity at around 2800-3100 cm -1 and smaller differences around 1460 cm -1 ; the bands can be assigned to protein vibrations. However, these are preliminary studies that provide a good basis for the development of a test for the initial diagnosis of mood disorders.
Keyphrases
- bipolar disorder
- sleep quality
- major depressive disorder
- depressive symptoms
- end stage renal disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- polycystic ovary syndrome
- metabolic syndrome
- prognostic factors
- type diabetes
- emergency department
- patient reported outcomes
- climate change
- single molecule
- risk assessment
- oxidative stress
- binding protein
- adipose tissue
- density functional theory
- adverse drug
- middle aged
- human health
- breast cancer risk
- electronic health record
- protein protein
- drug induced