Oleanolic acid ameliorates intestinal alterations associated with EAE.
Beatriz GutierrezIsabel GallardoLorena RuizYolanda AlvarezVictoria CachofeiroAbelardo MargollesMarita HernandezMaria Luisa NietoPublished in: Journal of neuroinflammation (2020)
These findings reveal that OA ameliorates the gut dysfunction found in EAE mice. OA normalizes the levels of gut mucosal dysfunction markers, as well as the pro- and anti-inflammatory immune bias during EAE, thus reinforcing the idea that OA is a beneficial compound for treating EAE and suggesting that OA may be an interesting candidate to be explored for the treatment of human MS.
Keyphrases
- knee osteoarthritis
- anti inflammatory
- endothelial cells
- oxidative stress
- mass spectrometry
- mouse model
- multiple sclerosis
- ms ms
- induced pluripotent stem cells
- gene expression
- high fat diet induced
- genome wide
- adipose tissue
- single cell
- metabolic syndrome
- skeletal muscle
- ulcerative colitis
- combination therapy
- replacement therapy
- insulin resistance
- dna methylation
- wild type