High-fat and high-sucrose diet impairs female reproduction by altering ovarian transcriptomic and metabolic signatures.

Congcong LiuYunde DouMengge ZhangShan HanShourui HuYuxuan LiZhiheng YuYue LiuXiaofan LiangZi-Jiang ChenHan ZhaoYuqing Zhang

Published in: Journal of translational medicine (2024)

Our results provide direct in vivo evidence for the detrimental effects of overnutrition on female reproduction and offer insights into the metabolic underpinnings of PCOS.

Keyphrases

physical activity
polycystic ovary syndrome
weight loss
single cell
genome wide
type diabetes
adipose tissue
gene expression
metabolic syndrome
skeletal muscle
insulin resistance