Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.
Jianjun XuTian ZhanWan ZhengYun-Ke HuangKen ChenXian-Hua ZhangPing RenXi HuangPublished in: Acta cirurgica brasileira (2021)
Taken together, all findings suggested that HSYA (30 mg/kg) are against TBI through improving the integrity in BBB, which are associated with the antioxidant, anti-inflammation and antiapoptosis via the probable mechanism of down-regulation of the TLR4/NF-kB pathway, and its in-detail protective mechanisms are under study.
Keyphrases
- oxidative stress
- blood brain barrier
- cerebral ischemia
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- traumatic brain injury
- spinal cord injury
- toll like receptor
- inflammatory response
- immune response
- white matter
- nuclear factor
- multiple sclerosis
- lps induced
- cell death
- severe traumatic brain injury
- subarachnoid hemorrhage