Induction of Apoptosis and Growth-Inhibition by Thymoquinone in ACHN and GP-293 Cell Lines in Comparable with Cis-Platinum.

Samira ShahrakiReza MohebbatiMohammad Naser ShafeiMahmoud MahmoudiSara HosseinianSoghra ParhizgarZohreh Naji Ebrahimi YazdNazanin Entezari HeraviReza Nejad Shahrokh AbadiAbolfazl Khajavirad

Published in: Journal of pharmacopuncture (2019)

Our findings demonstrated that TQ and Cis-platinum had cytotoxic and apoptotic effects on both cell lines, However, GP-293 cell line was more sensitive to TQ. Additionally, Cis-platinum was more effective on ACHN cell line than on GP-293 cell line.

Keyphrases

cell death
oxidative stress
endoplasmic reticulum stress
cell cycle arrest
cell proliferation
signaling pathway