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Sexually dimorphic effects of monoacylglycerol lipase inhibitor MJN110 on stress-related behaviors and drinking in Marchigian Sardinian alcohol-preferring rats.

Valentina VozellaBryan CruzHannah C FeldmanRyan BullardPaula C BianchiLuis A NatividadBenjamin F CravattEric P ZorrillaRoberto CiccocioppoMarisa Roberto
Published in: British journal of pharmacology (2023)
Acute inhibition of MAGL attenuated some stress-related responses in msP rats but not voluntary alcohol drinking. Our results provide new insights into the sex dimorphism documented in stress-induced responses and suggest that sex-specific endocannabinoid-based approaches should be considered in the clinical development of therapeutics.
Keyphrases
  • stress induced
  • alcohol consumption
  • drug induced
  • respiratory failure