Detection of direct oral anticoagulants with the diluted Russel's viper venom time.

Tristan KlöterMichael MetzeRonny KunzeStephan StöbeThomas SiegemundAnnelie SiegemundReinhard HenschlerUlrich LaufsSirak PetrosChristian Pfrepper

Published in: International journal of laboratory hematology (2024)

The dRVVT confirm assay (LA2) reliably detects residual DOAC plasma levels ≥30 ng/mL and could be useful to rapidly rule out relevant DOAC activity in emergency situations and to guide treatment decisions.

Keyphrases

direct oral anticoagulants
venous thromboembolism
atrial fibrillation
public health
emergency department
healthcare
high throughput
loop mediated isothermal amplification
label free
combination therapy
smoking cessation