AMPK-mTOR-Mediated Activation of Autophagy Promotes Formation of Dormant Polyploid Giant Cancer Cells.

Bo YouTian XiaMiao GuZhenxin ZhangQicheng ZhangJianhong ShenYue FanHui YaoSi PanYingna LuTianyi ChengZhiyuan YangXin HeHao ZhangMuqi ShiDong LiuYiwen You

Published in: Cancer research (2022)

Pretreatment with an autophagy inhibitor before chemotherapy could prevent formation of therapy-induced dormant polyploid giant cancer cells, thereby reducing recurrence and metastasis of nasopharyngeal carcinoma.

Keyphrases

cell death
endoplasmic reticulum stress
oxidative stress
signaling pathway
diabetic rats
high glucose
rare case
skeletal muscle
locally advanced
drug induced
free survival
stem cells
radiation therapy
mesenchymal stem cells