Monocytes Contribute to IFN-β Production via the MyD88-Dependent Pathway and Cytotoxic T-Cell Responses against Mucosal Respiratory Syncytial Virus Infection.
Tae Hoon KimChae Won KimDong Sun OhHi Eun JungHeung Kyu LeePublished in: Immune network (2021)
Respiratory syncytial virus (RSV) is the leading cause of respiratory viral infection in infants and children. However, little is known about the contribution of monocytes to antiviral responses against RSV infection. We identified the IFN-β production of monocytes using IFN-β/YFP reporter mice. The kinetic analysis of IFN-β-producing cells in in vivo RSV-infected lung cells indicated that monocytes are recruited to the inflamed lung during the early phase of infection. These cells produced IFN-β via the myeloid differentiation factor 88-mediated pathway, rather than the TLR7- or mitochondrial antiviral signaling protein-mediated pathway. In addition, monocyte-ablated mice exhibited decreased numbers of IFN-γ-producing and RSV Ag-specific CD8+ T cells. Collectively, these data indicate that monocytes play pivotal roles in cytotoxic T-cell responses and act as type I IFN producers during RSV infection.
Keyphrases
- respiratory syncytial virus
- dendritic cells
- immune response
- induced apoptosis
- cell cycle arrest
- peripheral blood
- respiratory tract
- young adults
- oxidative stress
- high fat diet induced
- type diabetes
- electronic health record
- endoplasmic reticulum stress
- bone marrow
- crispr cas
- signaling pathway
- endothelial cells
- small molecule
- artificial intelligence
- data analysis
- ulcerative colitis
- binding protein
- wild type