G6PD functions as a metabolic checkpoint to regulate granzyme B expression in tumor-specific cytotoxic T lymphocytes.

Chunwan LuDafeng YangJohn D KlementYolonda L ColsonNicholas H OberliesCedric J PearceAaron H ColbyMark W GrinstaffHan-Fei DingHuidong ShiZhuoqi Liu

Published in: Journal for immunotherapy of cancer (2022)

G6PD is a metabolic checkpoint in tumor-activated CTLs. The H3K9me3/G6PD/acetyl-CoA/H3K9ac/Gzmb pathway is particularly important in CTL activation and immune evasion in epithelioid mesothelioma.

Keyphrases

dna damage
cell cycle
cell proliferation