Interaction with hyaluronan matrix and miRNA cargo as contributors for in vitro potential of mesenchymal stem cell-derived extracellular vesicles in a model of human osteoarthritic synoviocytes.
Enrico RagniCarlotta Perucca OrfeiPaola De LucaGaia LuganoMarco ViganoAlessandra ColombiniFederico ValliDaniele ZacchettiValentina BollatiLaura de GirolamoPublished in: Stem cell research & therapy (2019)
Given their ability to affect FLS behavior in a model of chronic inflammation through direct interaction with HA matrix and miRNA release, ASC-EVs confirm their role as a novel therapeutic option for osteoarthritic joints.