Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4 + and CD8 + T Cells and Protects Against Recurrent Genital Herpes.

Afshana QuadiriSwayam PrakashNisha Rajeswari DhanushkodiMahmoud SingerLatifa ZayouAmin Mohammed ShaikMiyo SunBerfin SuzerLauren LauAmruth ChilukurriHawa VahedHubert SchaeferLbachir BenMohamed

Published in: bioRxiv : the preprint server for biology (2023)

A therapeutic RR2/CXCL11 prime/pull vaccine reduced recurrent genital herpes more effectively than therapeutic vaccination with a subunit HSV RR2 antigen alone.

Keyphrases

herpes simplex virus
patient safety
dendritic cells
working memory
regulatory t cells
immune response
quality improvement
small molecule
type iii
emergency medicine