Conjugation to a cell-penetrating peptide drives the tumour accumulation of the GLP1R antagonist exendin(9-39).
Estel Collado CampsSanne A M van LithAnnemarie KipCathelijne FrielinkLieke JoostenRoland BrockMartin GotthardtPublished in: European journal of nuclear medicine and molecular imaging (2022)
We demonstrate that penetratin robustly improves internalisation and tumour retention of exendin(9-39), opening new avenues for antagonist-based in vivo imaging of GLP1R.