Real-time whole genome sequencing to guide patient-tailored therapy of SARS-CoV-2 infection.
Luke Blagdon SnellAdela Medina-AlcoleaThemoula CharalampousChristopher AlderTom G S WilliamsFlavia FlavianiRahul BatraPrijay BakraniaRajeni ThangarajahStuart J D NeilClaire van Nispen Tot PannerdenAlina BotgrosEmma AaronsSamuel T DouthwaiteJonathan D EdgeworthGaia NebbiaPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
The management of COVID-19 has become more complex due to the expansion of available therapies. The presence of SARS-CoV-2 variants and mutations further complicate treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to characterise infections and guide treatment decisions.