Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine.
Jaclyn N HighlandPatrick J MorrisPanos ZanosJacqueline LovettSoumita GhoshAmy Q WangCarlos A ZarateCraig J ThomasRuin MoaddelTodd D GouldPublished in: Journal of psychopharmacology (Oxford, England) (2018)
These results demonstrate that (2R,6R)-hydroxynorketamine has favorable oral bioavailability in three species and exhibits antidepressant efficacy following oral administration in mice.