Long-term treatment with ivabradine in transgenic atrial fibrillation mice counteracts hyperpolarization-activated cyclic nucleotide gated channel overexpression.
Juan WangYan-Min YangYang LiJun ZhuHong LianXing-Hui ShaoHan ZhangYi-Cheng FuLian-Feng ZhangPublished in: Journal of cardiovascular electrophysiology (2018)
IVA reduced the incidence of AF in mice, and the antiarrhythmic effects of IVA are not limited to heart rate reduction, as they partially counteract HCN overexpression and reverse electrophysiological cardiac remodeling by attenuating If gain-of-function.
Keyphrases
- heart rate
- atrial fibrillation
- heart rate variability
- blood pressure
- high fat diet induced
- catheter ablation
- cell proliferation
- transcription factor
- left atrial
- risk factors
- heart failure
- left ventricular
- oral anticoagulants
- direct oral anticoagulants
- left atrial appendage
- type diabetes
- percutaneous coronary intervention
- insulin resistance
- combination therapy
- smoking cessation