Peppermint as a promising treatment agent in inflammatory conditions: A comprehensive systematic review of literature.
Mohammad Ali GoudarziMohammad RadfarZohreh GoudarziPublished in: Phytotherapy research : PTR (2023)
Inflammation, a type of the body's defense against injury or infection, causes many chronic disorders including diabetes, cardiovascular disease, and cancer. Therefore, discovering natural compounds with numerous biological activities for the management of inflammation is highly recommended. Out of natural compounds, peppermint and its main component, menthol, has been suggested to possess antiinflammatory potential. Four databases including Web of Sciences, PubMed, Scopus, and Embase were searched to identify articles about peppermint and its antiinflammatory effects up to March 2023. Out of 3805 records screened, 14 articles met the study criteria. The evidence reviewed here proposed peppermint as an antiinflammatory agent. Peppermint may suppress inflammation by activating the AMP-activated protein kinase/unc-51 like kinase 1/nuclear factor-E2 associated factor 2 autophagy pathway, downregulating extracellular signal-regulated kinase-nuclear factor kappa B and mitogen activated protein kinases pathways, attenuating oxidative stress, suppressing the production of pro-inflammatory mediators and nitric oxide, and inducing the production of antiinflammatory prostaglandins. Due to the promising antiinflammatory effects of peppermint and the lack of human studies in this regard, future randomized clinical trials examining the effects of peppermint on inflammation and its related maladies are warranted.
Keyphrases
- nuclear factor
- oxidative stress
- protein kinase
- toll like receptor
- cardiovascular disease
- nitric oxide
- type diabetes
- signaling pathway
- diabetic rats
- ischemia reperfusion injury
- induced apoptosis
- dna damage
- endothelial cells
- tyrosine kinase
- clinical trial
- cell death
- adipose tissue
- endoplasmic reticulum stress
- squamous cell carcinoma
- immune response
- transcription factor
- skeletal muscle
- young adults
- smoking cessation
- cardiovascular events
- papillary thyroid
- coronary artery disease
- nitric oxide synthase
- human health
- drug induced
- combination therapy