A calibration framework for the determination of accurate collision cross sections of polyanions using polyoxometalate standards.

Our novel calibration strategy for determination of CCS values of multiply negatively charged ions on TWIM-MS devices based on DT CCS (N2 ) of standard POM structures covered a wider range of CCS and improved the accuracy to 2.1% relative error on average compared with 6.9% using polyalanine and dextran calibration.