Presence of immunogenic alternatively spliced insulin gene product in human pancreatic delta cells.
René van TienhovenMaria J L KrachtArno R van der SlikSofia ThomaidouAnouk H G WoltersBen N G GiepmansJuan Pablo Romero RiojasMichael S NelsonFrancoise CarlottiEelco J P de KoningWytske M van WeerdenArnaud ZaldumbideBart O RoepPublished in: Diabetologia (2023)
The full EM dataset is available via www.nanotomy.org (for review: http://www.nanotomy.org/OA/Tienhoven2021SUB/6126-368/ ). Single-cell RNA-seq data was made available by Segerstolpe et al [13] and can be found at https://sandberglab.se/pancreas . The RNA and protein sequence of INS-splice was uploaded to GenBank (BankIt2546444 INS-splice OM489474).
Keyphrases
- rna seq
- single cell
- induced apoptosis
- endothelial cells
- type diabetes
- high throughput
- cell cycle arrest
- amino acid
- electronic health record
- big data
- genome wide
- induced pluripotent stem cells
- copy number
- endoplasmic reticulum stress
- knee osteoarthritis
- cell death
- gene expression
- binding protein
- machine learning
- oxidative stress
- cell proliferation
- small molecule
- deep learning
- insulin resistance