Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma.

Yuxiang MaXi ChenAo WangHongyun ZhaoQingguang LinHua BaoYang ZhangShaodong Hong Wanxiangfu TangYan HuangYunpeng YangXue WuYang ShaoWenfeng FangLi Zhang

Published in: Journal for immunotherapy of cancer (2021)

Anti-PD-1 treatment provided promising clinical benefit in pretreated patients with R/M NPC. Copy number loss in either GZMB or GZMH genes was associated with reduced survival.

Keyphrases

copy number
genome wide
mitochondrial dna
dna methylation
genome wide identification
gene expression
transcription factor