Clonal hematopoiesis, multi-omics and coronary artery disease.
Tetsushi NakaoPradeep NatarajanPublished in: Nature cardiovascular research (2022)
Studies of the genetic architecture of cardiovascular disease once focused on heritable germline factors. Newer work has shed light on the role of somatic mutations in blood cells. These mechanistic and multi-omics studies, along with phenotypic analyses, offer the prospect of new precision cardiovascular medicine paradigms.
Keyphrases
- cardiovascular disease
- coronary artery disease
- induced apoptosis
- single cell
- case control
- copy number
- cell cycle arrest
- cardiovascular events
- percutaneous coronary intervention
- type diabetes
- genome wide
- cell death
- gene expression
- oxidative stress
- coronary artery bypass grafting
- dna methylation
- signaling pathway
- left ventricular
- aortic stenosis
- ejection fraction