Pyrroles, furans, and thiophenes are important structural motifs in biologically active substances, pharmaceuticals and functional materials. In this paper, we disclose an efficient synthetic strategy for the rapid construction of multisubstituted pyrroles, furans, and thiophenes via NXS mediated desulfonylative/dehydrogenative cyclization of vinylidenecyclopropanes (VDCPs). The advantages of this method include wide substrate range, high efficiency and synthetic usefulness of the heterocyclic products under metal-free and mild conditions. The derivatization of pyrrole products and the preparation of functional molecules successfully demonstrated the synthetic potential of the products as platform molecules. The reaction mechanism has been investigated on the basis of control experiments and DFT calculations.
Keyphrases
- high efficiency
- density functional theory
- ms ms
- molecular dynamics
- liquid chromatography tandem mass spectrometry
- molecular dynamics simulations
- high performance liquid chromatography
- gas chromatography mass spectrometry
- molecular docking
- atomic force microscopy
- climate change
- mass spectrometry
- sensitive detection
- energy transfer
- single molecule
- structural basis