International Validation of the Immunoscore Biopsy in Patients With Rectal Cancer Managed by a Watch-and-Wait Strategy.
Carine El SissyAmos KirilovskyChristine Lagorce PagèsFlorence MarliotPetra A CustersEdina DizdarevicMarine SroussiMireia Castillo-MartinNacilla HaicheurMohamed DermaniNicolas LocheBénedicte ButtardAna Maria MusinaMaria-Gabriela AniţeiJosé G van den BergAnnegien BroeksSoledad IseasMariana CoraglioFernando Sanchez LoriaAlfredo RomeroPierre Laurent-PuigAurélien de ReynièsLaura M FernandezKaroui MedhiDavid TougeronCarlos Alberto VaccaroJuan P SantinoLaurids Østergaard PoulsenJan LindebjergJuan Manuel O'ConnorViorel ScripcariuMihail-Gabriel DimofteJean-Pierre GerardMyriam ChalabiNuno L FigueiredoRodrigo Oliva PerezAngelita Habr-GamaJerome GalonTorben Frøstrup HansenLars Henrik JensenGeerard L O BeetsGuy ZeitounFranck PagèsPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
is validated as a biomarker to predict both local regrowth and distant metastasis, with a gradual scaling of the risk of pejorative outcome.